一种用于检验疾病特征在家族性或其他类似的有序流行病学数据序列中发生的随机性的测试。
A test for the radomness of the occurrence of a disease trait in familial or other similar ordered sequences of epidemiological data.
作者信息
Chakraborty R, Weiss K M, Schull W J
出版信息
Proc Natl Acad Sci U S A. 1980 May;77(5):2974-8. doi: 10.1073/pnas.77.5.2974.
Through the construction of a probability distribution, a test is proposed for the randomness of the occurrence of an epidemiological event in a series of structured ordered sequences. Such sequences may be of persons admitted to hospital in some specified order, individuals seen in a large set of extended screening program, or individuals in a large set of extended genealogies. Modifications to account for the limited length of ascertained sequences are also given. The method will be particularly important in the first-stage evaluation of genealogical data to indicate the existence and degree of familial aggregation of diseases such as cancer and to justify more complex methods of analysis designed to evaluate the specific elements of causation that may be operating. The statistical power of this approach is also derived, considering the anticipated sample sizes in its application, to detect some forms of familial aggregation in a large genealogical data base from Laredo, Texas.
通过构建概率分布，提出了一种针对一系列结构化有序序列中流行病学事件发生随机性的检验方法。此类序列可能是按特定顺序入院的人员、在大型扩展筛查项目中接受检查的个体，或是大型扩展家谱中的个体。文中还给出了针对已确定序列长度有限的情况的修正方法。该方法在对家谱数据进行第一阶段评估时尤为重要，以表明癌症等疾病家族聚集的存在及程度，并为旨在评估可能起作用的具体病因要素而设计的更复杂分析方法提供依据。考虑到该方法应用中的预期样本量，还推导了其统计功效，以检测来自得克萨斯州拉雷多的大型家谱数据库中的某些家族聚集形式。
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