Donham K J, Berg J W, Sawin R S
Am J Epidemiol. 1980 Jul;112(1):80-92. doi: 10.1093/oxfordjournals.aje.a112979.
Data from the Third National Cancer Survey and data collected under the auspices of the National Cancer Institute's Surveillance, Epidemiologic and End Results (SEER) Program were used to perform a descriptive epidemiologic study of leukemia in Iowa. Data were also collected on livestock population patterns in the state, and a survey was performed to locate cases of lymphosarcoma within the cattle population. Ecologic relationships between human leukemia, livestock populations and bovine lymphosarcoma were investigated. Iowa has higher rates than the national average for human leukemias. The lymphoid leukemias make up the majority of the excess leukemias. Excessive acute lymphoid leukemia (ALL) is seen in the ages under 20 years and over 60 years. The excess ALL is in males living in rural counties. There is no sex difference for chronic lymphoid leukemia (CLL), but there is a slight urban-rural differential. There is a high positive correlation between ALL in males and cattle density. This relationship is greater for daily cattle than for beef cattle. There is an additional positive relationship between counties with excessive ALL and the presence of dairy herds affected with bovine lymphosarcoma.
来自第三次全国癌症调查的数据以及在美国国立癌症研究所监测、流行病学和最终结果（SEER）计划主持下收集的数据，被用于对爱荷华州的白血病进行描述性流行病学研究。还收集了该州牲畜种群模式的数据，并开展了一项调查以确定牛群中的淋巴肉瘤病例。对人类白血病、牲畜种群和牛淋巴肉瘤之间的生态关系进行了调查。爱荷华州人类白血病发病率高于全国平均水平。淋巴性白血病占超额白血病的大多数。20岁以下和60岁以上人群中急性淋巴细胞白血病（ALL）过多。超额的ALL见于居住在农村县的男性。慢性淋巴细胞白血病（CLL）不存在性别差异，但存在轻微的城乡差异。男性ALL与牛群密度之间存在高度正相关。这种关系在奶牛中比在肉牛中更明显。ALL过多的县与受牛淋巴肉瘤影响的奶牛群的存在之间还存在正相关关系。
