Dohy H, Genot J Y, Imbert M, D'Agay M F, Sultan C
Clin Lab Haematol. 1980;2(2):111-9. doi: 10.1111/j.1365-2257.1980.tb00814.x.
Clinical and haematological features of 13 patients with secondary myelodysplastic syndromes (MDS) were studied, MDS developed subsequent to chemotherapy and/or radiotherapy for various haematological or non-haematological diseases. In six cases, the first sign was a persistently increased mean cell volume (MCV) and a macrocytosis preceding from 6 to 18 months the appearance of severe anaemia or acute leukaemia. In five cases, the initial finding was a macrocytic anaemia. Dysmyelopoiesis was a constant and prominent feature of the bone marrow smears at some time during the course of the disease. Two cases without macrocytosis at any time directly developed overt acute leukaemia.
对13例继发性骨髓增生异常综合征（MDS）患者的临床和血液学特征进行了研究，这些MDS是在针对各种血液学或非血液学疾病进行化疗和/或放疗后发生的。在6例患者中，首个体征是平均红细胞体积（MCV）持续升高以及大细胞性贫血，在严重贫血或急性白血病出现前6至18个月就已存在。在5例患者中，最初的表现是大细胞性贫血。在疾病过程中的某个时候，骨髓涂片上的异常髓系造血是一个持续且突出的特征。有2例在任何时候均无大细胞性贫血，而是直接发展为明显的急性白血病。
