搭便车效应：连锁与部分自交的比较
Hitchhiking: a comparison of linkage and partial selfing.
作者信息
Hedrick P W
出版信息
Genetics. 1980 Mar;94(3):791-808. doi: 10.1093/genetics/94.3.791.
Genetic hitchhiking occurs when alleles at unselected loci are changed in frequency because of an association with alleles at a selected locus. This association may be mediated either by linkage or partial selfing (inbreeding) and can affect the gene frequency and gametic disequilibrium at the neutral loci. Hitchhiking from partial selfing (unlinked loci) occurs more quickly than linkage hitchhiking and generally has a greater effect. In addition, partial-selfing hitchhiking can cause increases or changes in sign in gametic disequilibrium between neutral loci. The effects of the two types of hitchhiking with different levels of dominance, zygotic frequencies and number of selected loci are also examined. The general conditions for linkage and partial-selfing hitchhiking are outlined and the implications of hitchhiking are discussed for marker or electrophoretic loci.
当未被选择的基因座上的等位基因由于与被选择基因座上的等位基因相关联而在频率上发生改变时，就会出现遗传搭便车现象。这种关联可能由连锁或部分自交（近亲繁殖）介导，并会影响中性基因座的基因频率和配子不平衡。部分自交（不连锁基因座）导致的遗传搭便车比连锁遗传搭便车发生得更快，而且通常影响更大。此外，部分自交遗传搭便车会导致中性基因座之间配子不平衡的增加或符号变化。研究了两种不同显性水平、合子频率和被选择基因座数量的遗传搭便车效应。概述了连锁和部分自交遗传搭便车的一般条件，并讨论了遗传搭便车对标记或电泳基因座的影响。
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