Ogaard B, Gjermo P, Rølla G
Am J Orthod. 1980 Sep;78(3):266-72. doi: 10.1016/0002-9416(80)90271-7.
The present investigation was undertaken to study the plaque-inhibiting effect of a dentifrice containing stannous fluoride/stannous pyrophosphate during treatment with fixed orthodontic appliances. The test toothpaste was compared with sodium monofluorophosphate toothpaste and paste without fluoride and tin. When applied directly on the teeth, the test paste was found to reduce plaque growth significantly for 24 hours (P < 0.001). A double-blind cross-over designed study with twenty-one subjects showed statistically significant plaque inhibition after a 3-week test period on subjects showed statistically significant plaque inhibition after a 3-week test period on subjects showed statistically significant plaque inhibition after a 3-week test period on teeth with the appliances placed more than 1.5 mm. from the gingival margin (P < 0.01). Plaque reduction on teeth with the appliances placed close to the gingival margin was not statistically significant (P > 0.05). No statistically significant improvement in the gingival condition and no side effects were observed. It is concluded that because of its dual action on plaque and teeth stannous fluoride/stannous pyrophosphate toothpaste may be recommended as supplement to and not substitute for other forms of fluoride supplementation in this category of patients.
本研究旨在探讨含氟化亚锡/焦磷酸亚锡的牙膏在固定正畸矫治器治疗期间的防牙菌斑作用。将受试牙膏与单氟磷酸钠牙膏以及不含氟和锡的牙膏进行比较。当直接涂抹于牙齿上时，发现受试牙膏在24小时内可显著减少牙菌斑生长（P<0.001）。一项针对21名受试者的双盲交叉设计研究表明，在为期3周的测试期后，对于矫治器距离牙龈边缘超过1.5毫米的牙齿，牙菌斑抑制具有统计学意义（P<0.01）。矫治器靠近牙龈边缘的牙齿上的牙菌斑减少无统计学意义（P>0.05）。未观察到牙龈状况有统计学意义的改善，也未观察到副作用。结论是，由于氟化亚锡/焦磷酸亚锡牙膏对牙菌斑和牙齿具有双重作用，在这类患者中，可推荐其作为其他形式氟补充剂的补充，而非替代品。
