口腔天疱疮与慢性淋巴细胞白血病的关联。

Association of oral pemphigus with chronic lymphocytic leukemia.

作者信息

Laskaris G C, Papavasiliou S S, Bovopoulou O D, Nicolis G D

出版信息

Oral Surg Oral Med Oral Pathol. 1980 Sep;50(3):244-9. doi: 10.1016/0030-4220(80)90378-3.

PMID:6931999

Abstract

Pemphigus is a bullous autoimmune disease of the skin and mucosae. Recently pemphigus has been associated with malignant disorders originating from several tissues. Two cases of oral pemphigus associated with chronic lymphocytic leukemia are reported. Direct immunofluorescence studies of oral biopsy material showed a pattern consistent with pemphigus in both cases. The nature of the anti-ICS antibodies was IgG. However, in one case anti-ICS antibodies were detected in the serum while in the other anti-striated-muscle autoantibodies were present. The clinical course and interrelationship of the two disorders are discussed.

摘要

天疱疮是一种皮肤和黏膜的大疱性自身免疫性疾病。最近，天疱疮与源自多个组织的恶性疾病有关。本文报告了2例与慢性淋巴细胞白血病相关的口腔天疱疮病例。对口腔活检材料进行的直接免疫荧光研究表明，两例病例的模式均与天疱疮一致。抗细胞间物质（ICS）抗体的性质为IgG。然而，1例病例血清中检测到抗ICS抗体，另1例病例则存在抗横纹肌自身抗体。本文还讨论了这两种疾病的临床病程及相互关系。