H-2K和H-2D抗原的选择性周转和脱落受主要组织相容性复合体控制。对H-2限制性识别的影响。
Selective turnover and shedding of H-2K and H-2D antigens is controlled by the major histocompatibility complex. Implications for H-2-restricted recognition.
作者信息
Emerson S G, Murphy D B, Cone R E
出版信息
J Exp Med. 1980 Oct 1;152(4):783-95. doi: 10.1084/jem.152.4.783.
Abstract
Lactoperoxidase-catalyzed cell surface radioiodination and incorporation of [3H]-leucine were employed to radiolabel H-2K and H-2D antigens of murine spleen cells. The fate of H-2 antigens was monitored by in vitro culture of labeled cells and isolation of labeled antigens from detergent lysates of the cells and culture supernates obtained at different times during culture. H-2Kk antigens were found to be rapidly turned over and shed by CBA/J cells, whereas the turnover of H-2Dk antigens was extremely slow. Analysis of the membrane residence times of surface-labeled H-2K and H-2D antigens on spleen cells from various H-2-congenic and -recombinant strains demonstrated variations in the shedding rates of H-2K and H-2D antigens, which were controlled by genes mapping in the major histocompatibility complex. These variations show a striking correlation with published, genetically controlled quantitative variations in the cytotoxic response of T lymphocytes to chemically modified or virus-infected syngeneic cells.
摘要
采用乳过氧化物酶催化的细胞表面放射性碘化和[3H] - 亮氨酸掺入法对小鼠脾细胞的H - 2K和H - 2D抗原进行放射性标记。通过对标记细胞进行体外培养，并从细胞去污剂裂解物和培养不同时间获得的培养上清液中分离标记抗原，监测H - 2抗原的命运。发现CBA/J细胞能快速周转并释放H - 2Kk抗原，而H - 2Dk抗原的周转极其缓慢。对来自各种H - 2同基因和重组品系脾细胞表面标记的H - 2K和H - 2D抗原的膜停留时间分析表明，H - 2K和H - 2D抗原的脱落率存在差异，这些差异受主要组织相容性复合体中定位基因的控制。这些差异与已发表的、T淋巴细胞对化学修饰或病毒感染的同基因细胞的细胞毒性反应中基因控制的定量差异显著相关。
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