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与α干扰素和β干扰素相比，人γ干扰素能更有效地增强肿瘤细胞中I类和II类主要组织相容性复合体产物的表达。

Human interferon-gamma enhances the expression of class I and class II major histocompatibility complex products in neoplastic cells more effectively than interferon-alpha and interferon-beta.

作者信息

Dolei A, Capobianchi M R, Ameglio F

出版信息

Infect Immun. 1983 Apr;40(1):172-6. doi: 10.1128/iai.40.1.172-176.1983.

DOI:10.1128/iai.40.1.172-176.1983
PMID:6299957
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC264832/
Abstract

Human interferon-gamma was more effective than interferon-beta or -alpha in stimulating production of immunoassociated antigens; HLA-A, -B, and -C; and beta(2)-microglobulin in human M14 and Namalva cells. The comparison was made on the basis of antiviral units, and the stimulation could be abolished by treatment of the interferon-gamma preparation with pH 2 or anti-interferon-gamma serum.

摘要

在刺激人M14和Namalva细胞产生免疫相关抗原、HLA - A、- B和 - C以及β2 - 微球蛋白方面，人γ干扰素比β干扰素或α干扰素更有效。该比较是基于抗病毒单位进行的，并且用pH 2处理γ干扰素制剂或抗γ干扰素血清可消除这种刺激作用。

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1
Human interferon-gamma enhances the expression of class I and class II major histocompatibility complex products in neoplastic cells more effectively than interferon-alpha and interferon-beta.与α干扰素和β干扰素相比，人γ干扰素能更有效地增强肿瘤细胞中I类和II类主要组织相容性复合体产物的表达。
Infect Immun. 1983 Apr;40(1):172-6. doi: 10.1128/iai.40.1.172-176.1983.
2
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本文引用的文献

1
HLA-DR typing by radioimmunoassay.通过放射免疫测定法进行 HLA - DR 分型。
Transplantation. 1980 Apr;29(4):302-5. doi: 10.1097/00007890-198004000-00008.
2
Immune and virus-induced interferons may activate cells by different derepressional mechanisms.免疫和病毒诱导的干扰素可能通过不同的去抑制机制激活细胞。
Nature. 1980 Jan 24;283(5745):400-2. doi: 10.1038/283400a0.
3
Purified human immune interferon has more potent anticellular activity than fibroblast or leukocyte interferon.纯化的人免疫干扰素比成纤维细胞干扰素或白细胞干扰素具有更强的抗细胞活性。
Cell Immunol. 1980 Feb;49(2):390-4. doi: 10.1016/0008-8749(80)90041-6.
4
Why the MHC is important to the immune system.为何主要组织相容性复合体对免疫系统至关重要。
Transplant Proc. 1981 Dec;13(4):1797-9.
5
Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes.不同H-2单倍型小鼠中Eα和Ae（Eβ）Ia多肽链的可变合成与表达
Immunogenetics. 1981;12(3-4):321-37. doi: 10.1007/BF01561674.
6
Selective turnover and shedding of H-2K and H-2D antigens is controlled by the major histocompatibility complex. Implications for H-2-restricted recognition.H-2K和H-2D抗原的选择性周转和脱落受主要组织相容性复合体控制。对H-2限制性识别的影响。
J Exp Med. 1980 Oct 1;152(4):783-95. doi: 10.1084/jem.152.4.783.
7
Molecular identification of human Ia antigens coded for by a gene locus closely linked to HLA-DR locus.由与HLA - DR基因座紧密连锁的基因座编码的人类Ia抗原的分子鉴定。
Immunogenetics. 1980;10(2):151-67. doi: 10.1007/BF01561564.
8
Production and purification of the human interferon gamma (HuIFN-gamma).
Tex Rep Biol Med. 1981;41:179-83.
9
Effect of interferon on erythropoietic differentiation.干扰素对红细胞生成分化的影响。
Tex Rep Biol Med. 1981;41:381-7.
10
Potentiation of the direct anticellular activity of mouse interferons: mutual synergism and interferon concentration dependence.小鼠干扰素直接抗细胞活性的增强：相互协同作用及干扰素浓度依赖性
Cancer Res. 1982 Mar;42(3):869-75.