Hayes C E, Bach F H
J Exp Med. 1980 Feb 1;151(2):481-5. doi: 10.1084/jem.151.2.481.
Strong, primary mixed leukocyte culture-proliferative responses in certain K region-incompatible strain combinations led us to consider whether an I region-like locus might exist between K and I-A. Results obtained with an (A. TL X B10.D2)F1 anti-B10.BR serum provided serological evidence for a new locus; B10.T(6R)-absorbed serum retained reactivity on AQR lymphocytes. This finding demonstrates an antigen, Ia.W41, encoded by a locus, Ia-7, within a new I subregion, I-N.
某些K区域不相容品系组合中强烈的原发性混合白细胞培养增殖反应,使我们思考在K和I-A之间是否可能存在一个类似I区域的基因座。用(A.TL×B10.D2)F1抗B10.BR血清获得的结果为一个新基因座提供了血清学证据;B10.T(6R)吸收的血清在AQR淋巴细胞上保留了反应性。这一发现证明了一种由位于新的I子区域I-N内的Ia-7基因座编码的抗原Ia.W41。