Eschenbach C, Schmitz-Moormann P, Gutjahr P
Klin Padiatr. 1980 Mar;192(2):130-3. doi: 10.1055/s-2008-1033871.
A case of hepatocellular carcinoma following acute lymphoblastic leukemia (ALL) in childhood is described. After completion of the combined therapy of ALL, there was splenogenic thrombocytopenia which was successfully treated by splenectomy. Cirrhosis of the liver and HBs antigen-positive hepatitis was detected by biopsy. The cirrhosis progressed during the following year. After a further year a hepatocellular carcinoma was diagnosed. This gave rise to the death of the patient in complete hematological remission 5 years and 7 months after commencement and 2 years and 10 months after completion of the ALL therapy. Only two cases of hepatocellular carcinoma following ALL at this age have been reported by other authors.
本文描述了一例儿童急性淋巴细胞白血病（ALL）后发生肝细胞癌的病例。ALL联合治疗结束后，出现脾源性血小板减少症，通过脾切除术成功治疗。活检发现肝硬化和乙肝表面抗原阳性肝炎。肝硬化在接下来的一年中进展。又过了一年，诊断出肝细胞癌。这导致患者在ALL治疗开始5年7个月后、结束2年10个月后，在完全血液学缓解状态下死亡。其他作者仅报道过两例这个年龄段ALL后发生肝细胞癌的病例。
