视网膜母细胞瘤经钴板治疗后发生的肱骨骨肉瘤。
Osteogenic sarcoma of the humerus after cobalt plaque treatment for retinoblastoma.
作者信息
Abramson D H, Ellsworth R M, Kitchin F D
出版信息
Am J Ophthalmol. 1980 Sep;90(3):374-6. doi: 10.1016/s0002-9394(14)74919-0.
A 13-year-old boy developed an osteogenic sarcoma of the right humerus ten years after treatment for bilateral retinoblastoma. The bilateral retinoblastoma has been managed with enucleation of one eye and successful treatment of the solitary tumor in the other eye with a single application of a local 10-mm round cobalt plaque. Patients with bilateral retinoblastoma have a significant (15 to 20%) chance of developing a second, nonocular, neoplasm. These neoplasms have occurred from one to 42 years after the treatment for retinoblastoma. The most common of these tumors is an osteogenic sarcoma; it may occur after external beam irradiation, local cobalt plaque, or no irradiation. The tumors may be in the skull or at distant sites whether or not these patients receive radiation.
一名13岁男孩在双侧视网膜母细胞瘤治疗十年后发生了右肱骨骨肉瘤。双侧视网膜母细胞瘤的治疗方法是摘除一只眼睛，并通过单次应用局部10毫米圆形钴板成功治疗另一只眼睛的孤立肿瘤。双侧视网膜母细胞瘤患者发生第二种非眼部肿瘤的几率显著（15%至20%）。这些肿瘤在视网膜母细胞瘤治疗后1至42年出现。其中最常见的肿瘤是骨肉瘤；它可能在外部束照射、局部钴板照射或未照射后发生。无论这些患者是否接受放疗，肿瘤可能发生在颅骨或远处部位。
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