实验性肿瘤系统的选择
The choice of experimental tumour systems.
作者信息
Scott O C
出版信息
Br J Cancer Suppl. 1980 Apr;4:112-7.
Abstract
One of the commonest systems in use in cancer research today is the transplanted tumour in an inbred strain of mice. Reasons are given for suspecting that inbred mice may not be as well-defined genetically as has been supposed. The oft-quoted figure of 20 generations of brother-sister mating appears to be based on the assumption that heterozygosity at only one gene locus is involved in the foundation mating.
摘要
当今癌症研究中最常用的系统之一是在近交系小鼠中移植肿瘤。有理由怀疑近交小鼠在基因上可能不像人们所认为的那样明确。经常被引用的20代兄妹交配的数据似乎是基于这样一种假设，即基础交配中仅涉及一个基因座的杂合性。
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本文引用的文献
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Atrophy of tumors caused by strangulation and accompanied by development of tumor immunity in rats.大鼠中由绞窄引起的肿瘤萎缩并伴有肿瘤免疫的发展。
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Some aspects of the effect of ionizing radiation on tumors in experimental animals.电离辐射对实验动物肿瘤影响的某些方面。
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Skin compatibility of different CBA sublines separated from each other in the course of a varying number of generations.在不同代数过程中彼此分离的不同CBA亚系的皮肤相容性。
Transplantation. 1963 Jan;1:58-60. doi: 10.1097/00007890-196301010-00006.
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Some observations on the use of transplanted tumors in radiobiological research.关于移植性肿瘤在放射生物学研究中的应用的一些观察
Radiat Res. 1961 May;14:643-52.
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Sex-linked rejection of normal and neoplastic tissue. I. Distribution and specificity.正常组织和肿瘤组织的性连锁排斥反应。I. 分布与特异性
J Natl Cancer Inst. 1958 Mar;20(3):563-75.
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Studies on radiosensitivity and immunizing ability of mammary tumours of mice.小鼠乳腺肿瘤的放射敏感性和免疫能力研究。
Br J Cancer. 1954 Jun;8(2):320-35. doi: 10.1038/bjc.1954.33.
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A test for histocompatibility between sublines of the CBA strain of mice.小鼠CBA品系亚系之间组织相容性的检测。
Transplantation. 1965 Nov;3(6):766-8.
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