Cairo M S, Lazarus K, Gilmore R L, Baehner R L
J Pediatr. 1980 Nov;97(5):829-33. doi: 10.1016/s0022-3476(80)80281-2.
L-Asparaginase is commonly used for induction therapy of acute lymphocytic leukemia of childhood. Severe clinical bleeding secondary to clotting dysfunction has not been previously reported. We observed intracranial hemorrhagic infarcts with focal seizures and hemiparesis associated with clotting abnormalities, including severe hypofibrinogenemia, probably the result of L-asparaginase administered during induction therapy of acute lymphocytic leukemia.
L-天冬酰胺酶常用于儿童急性淋巴细胞白血病的诱导治疗。此前尚未报道过因凝血功能障碍继发的严重临床出血情况。我们观察到颅内出血性梗死伴局灶性癫痫发作和偏瘫，与凝血异常有关，包括严重的低纤维蛋白原血症，这可能是急性淋巴细胞白血病诱导治疗期间使用L-天冬酰胺酶的结果。
