Sills R H, Nelson D A, Stockman J A
Med Pediatr Oncol. 1978;4(4):311-3. doi: 10.1002/mpo.2950040406.
L-Asparaginase-induced coagulation abnormalities were observed in all patients receivng this drug. All patients studied demonstrated low factor IX and fibrinogen levels and most (75%) had low levels of factor XI. Disturbances in other factors were much less frequent. Despite the presence of markedly abnormal coagulation studies, clinical bleeding was not observed.
在所有接受这种药物治疗的患者中均观察到L-天冬酰胺酶诱导的凝血异常。所有研究的患者均显示因子IX和纤维蛋白原水平降低，且大多数（75%）患者的因子XI水平较低。其他因子的紊乱则不太常见。尽管凝血研究结果明显异常，但未观察到临床出血情况。
