Urban C, Sager W D
Eur J Pediatr. 1981 Nov;137(3):323-7. doi: 10.1007/BF00443266.
Two patients developed clinical features of intracranial bleeding--which were confirmed by computerized axial tomograms--during their induction therapy for acute lymphocytic leukemia. Coagulation studies showed clotting abnormalities including severe hypofibrinogenemia. These findings most probably were related to the effect of L-asparaginase which was part of the treatment protocol. Central nervous system leukemia, intrathecal chemotherapy, cranial irradiation, extreme leukocytosis, or thrombopenia at the time of diagnosis or day of stroke did not appear to be predisposing factors in these cases.
两名急性淋巴细胞白血病患者在诱导治疗期间出现颅内出血的临床症状，经计算机断层扫描证实。凝血研究显示存在凝血异常，包括严重的低纤维蛋白原血症。这些发现很可能与治疗方案中使用的L-天冬酰胺酶的作用有关。在这些病例中，中枢神经系统白血病、鞘内化疗、颅脑照射、极度白细胞增多或诊断时或中风当天的血小板减少似乎都不是诱发因素。
