Miller T E, Ormrod D
N Z Med J. 1980 Sep 10;92(667):187-93.
The anti-inflammatory effect of a crude fraction of the New Zealand green lipped mussel (Perna canaliculus) has been investigated. A carrageenan-induced inflammatory oedema of the rat hind footpad was used as the experimental model. Non-steroidal anti-inflammatory agents were first shown to be capable of reducing the inflammatory oedema and in the subsequent experiments a representative agent was included as a reference substance. The preparation, Perna canaliculus, effectively reduced the footpad oedema but only if injected into the peritoneal cavity. Decreasing amounts were given IP and 500 mg/kg of the crude preparation was found to be the lowest single dose that would produce a significant reduction in the inflammatory response to carrageenan. Lower doses were effective if the substance was first administered daily for several days, prior to the challenge. Oral administration was not effective in reducing the inflammatory response.
对新西兰绿唇贻贝（Perna canaliculus）粗提物的抗炎作用进行了研究。以角叉菜胶诱导的大鼠后足爪炎性水肿作为实验模型。非甾体抗炎药首先被证明能够减轻炎性水肿，在随后的实验中，将一种代表性药物作为参考物质。制备的绿唇贻贝提取物能有效减轻足爪水肿，但仅在腹腔注射时有效。腹腔注射剂量逐渐减少，发现500 mg/kg的粗提物是能使对角叉菜胶的炎症反应显著减轻的最低单剂量。如果在激发前先连续几天每日给药，较低剂量也有效。口服给药对减轻炎症反应无效。
