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北美印第安人和埃蒂土耳其人中的白蛋白纳斯卡皮变体。

Albumin Naskapi variant in North American Indians and Eti Turks.

作者信息

Franklin S G, Wolf S I, Ozdemir Y, Yüregir G T, Isbir T, Blumberg B S

出版信息

Proc Natl Acad Sci U S A. 1980 Sep;77(9):5480-2. doi: 10.1073/pnas.77.9.5480.

Abstract

Both conventional polyacrylamide gel electrophoresis and a new type of electrophoretic screening procedure indicate that the polymorphic albumin variants Naskapi, found chiefly in the Naskapi Indians of Quebec, and Mersin, found in the Eti Turks of southeastern Turkey, are molecularly identical or very similar and that the amino acid substitution site in these variants is located between residues 330 and 446. This discovery is consistent with a genetic relationship between the Eti Turks and American Indians. We also report a new variant found in the Eti Turks, albumin Adana, which migrates similarly to albumin B on conventional gels but which our new system shows to differ from the common albumin A and albumin B by a substitution between residues 549 and 585.

摘要

传统的聚丙烯酰胺凝胶电泳和一种新型的电泳筛选程序均表明,主要在魁北克的纳斯卡皮印第安人中发现的多态性白蛋白变体纳斯卡皮,以及在土耳其东南部的埃蒂土耳其人中发现的梅尔辛,在分子层面上是相同的或非常相似的,并且这些变体中的氨基酸取代位点位于第330位和第446位残基之间。这一发现与埃蒂土耳其人和美洲印第安人之间的遗传关系相符。我们还报告了在埃蒂土耳其人中发现的一种新变体,白蛋白阿达纳,它在传统凝胶上的迁移情况与白蛋白B相似,但我们的新系统显示它与常见的白蛋白A和白蛋白B在第549位和第585位残基之间存在一个取代差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64c4/350084/0d1fb85e2577/pnas00496-0464-a.jpg

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