残杀威在大鼠体内的代谢情况

The fate of propoxur in rat.

作者信息

Foss W, Krechniak J

出版信息

Arch Toxicol Suppl. 1980;4:346-9. doi: 10.1007/978-3-642-67729-8_74.

Abstract

The dynamics of absorption, distribution, biotransformation, and excretion of propoxur in rat was studied. The animals were given single doses of propoxur: a) 5 mg/kg intravenously (i.v.), b) 5 mg/kg 14-C labelled compound (1.5 muCi) intravenously, c) 50 mg/kg orally. The concentrations of propoxur and its metabolite 2-isopropoxyphenol were determined in blood, liver, kidneys, brain and urine. Pharmacokinetic data concerning absorption, distribution and excretion were calculated.

摘要

研究了残杀威在大鼠体内的吸收、分布、生物转化及排泄动力学。给动物单次给予残杀威：a）静脉注射5毫克/千克；b）静脉注射5毫克/千克的14-C标记化合物（1.5微居里）；c）口服50毫克/千克。测定了血液、肝脏、肾脏、大脑和尿液中残杀威及其代谢物2-异丙氧基苯酚的浓度。计算了有关吸收、分布和排泄的药代动力学数据。