Wysocka-Paruszewska B, Osicka A, Brzeziński J, Gradowska I
Arch Toxicol Suppl. 1980;4:449-51. doi: 10.1007/978-3-642-67729-8_105.
Combined action of Thiuram with Carbaryl, Propoxur, Pirimor, Chlorfenvinphos, Malathion, Lindane, and Carbendazine was investigated in rats. The effects induced by Thiuram containing combinations were stronger in females than in males. The type of response was differentiated in each individual case. In rats receiving Chlorfenvinphos or Carbendazine with Thiuram the effects were on the borderline between more than additive and potentiated toxicity in males, while in females potentiation was observed. In the case of the combination with Propoxur the effects appeared to be less than additive in males and strictly additive in females. Other tested combinations exerted additive action in males, while in females effects ranged from additive to potentiating toxicity. It is evident, that combined action of Thiuram with some pesticides might have resulted in potentiation of toxicity. Hence, this fact ought to be considered in evaluation of Thiuram containing multicomponent pesticidal preparations that are to be introduced into practical use.
研究了福美双与西维因、残杀威、抗蚜威、毒虫畏、马拉硫磷、林丹和多菌灵在大鼠体内的联合作用。含福美双的组合对雌性大鼠的诱导作用强于雄性大鼠。在每个单独的案例中，反应类型有所不同。在接受毒虫畏或多菌灵与福美双组合的大鼠中，雄性大鼠的效应处于相加毒性和增强毒性之间的临界状态，而雌性大鼠则观察到毒性增强。在与残杀威组合的情况下，雄性大鼠的效应似乎小于相加作用，而雌性大鼠则为严格的相加作用。其他测试组合在雄性大鼠中表现为相加作用，而在雌性大鼠中，效应范围从相加到增强毒性。显然，福美双与某些农药的联合作用可能导致毒性增强。因此，在评估即将投入实际使用的含福美双的多组分农药制剂时，应考虑这一事实。
