癌症患者唾液与血清凝集效价及放疗后龋齿活性之间的关系。

Relationship between saliva and serum agglutination titers and post-irradiation caries activity in cancer patients.

作者信息

Brown L R, O'Neill P A, Dreizen S, Handler S F, Riggan L J, Perkins D H

出版信息

J Dent Res. 1981 Jan;60(1):10-8. doi: 10.1177/00220345810600010101.

DOI:10.1177/00220345810600010101

Abstract

Agglutination titers in 444 saliva and 481 serum samples from 36 head and neck cancer patients and 16 control subjects were determined against formalinized cellular antigens of Streptococcus and Lactobacillus species. Saliva agglutination titers were significantly higher in cancer patients before radiotherapy than in control subjects. Changes in specific saliva agglutination titers to oral isolates following radiotherapy reflected changes in saliva IgA and post-irradiation caries activity. Patients with no post-irradiation caries activity had significantly higher saliva agglutination titers to S. mutans, S. sanguis, and L. fermenti, lower plaque S. mutans counts, and higher saliva IgA levels than those with post-irradiation caries activity. Serum agglutination titers were unrelated to either serum immunoglobulin levels, microbial counts, or caries activity.

摘要

对36例头颈癌患者和16例对照受试者的444份唾液样本和481份血清样本，测定了针对链球菌属和乳杆菌属甲醛固定细胞抗原的凝集效价。放疗前癌症患者的唾液凝集效价显著高于对照受试者。放疗后针对口腔分离株的特异性唾液凝集效价变化反映了唾液IgA和放疗后龋齿活性的变化。与有放疗后龋齿活性的患者相比，没有放疗后龋齿活性的患者对变形链球菌、血链球菌和发酵乳杆菌的唾液凝集效价显著更高，菌斑中变形链球菌计数更低，唾液IgA水平更高。血清凝集效价与血清免疫球蛋白水平、微生物计数或龋齿活性均无关。