酶催化与能量偶联之间的关系。
Relation between enzymic catalysis and energy coupling.
作者信息
Fry M, Blondin G A, Green D E
出版信息
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5703-5. doi: 10.1073/pnas.77.10.5703.
The principles that underlie enzyme catalysis also apply to energy coupling processes. A comparison is made between a kinase system that mediates the phosphorylation of glucose by ATP (hexokinase), as the prototype for enzymic catalysis, and the mitochondrial electron-transfer complexes, as the prototypes for energy coupling systems. Induced polarization of chemical bonds and charge separation and elimination are common component events of both enzyme catalysis and energy coupling. Thus, definite limits can be imposed on models of energy coupling; they must comply with the basic principles of enzymic catalysis.
酶催化所依据的原理也适用于能量偶联过程。以介导ATP将葡萄糖磷酸化的激酶系统（己糖激酶）作为酶催化的原型，与作为能量偶联系统原型的线粒体电子传递复合体进行了比较。化学键的诱导极化以及电荷分离和消除是酶催化和能量偶联共同的组成事件。因此，可以对能量偶联模型设定明确的限制；它们必须符合酶催化的基本原理。
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