Cytryn A S
Psychiatry Res. 1980 Sep;3(1):41-51. doi: 10.1016/0165-1781(80)90046-3.
The effect of varying doses of d-amphetamine on the activity level of C57BL/6J mice (known for their high activity level), DBA/1J, C3H/HeJ, and C3D2F1 mice was investigated (all mice were 25 to 30 days old). Activity was measured by the use of an activity cage with a revolving drum. After determination of baseline activity level, the animals were assigned to the following set of i.p. injections: (1) normal saline, (2) d-amphetamine 0.2 mg/kg, (3) d-amphetamine 0.5 mg/kg, (4) d-amphetamine 5 mg/kg. The mean activity level of the C57BL/6J mice was significantly higher than that of the other strains. The mean activity level after 5 mg/kg was significantly lower than after other dosages in all strains. All strains responded similarly to d-amphetamine as is apparent from the parallel profiles for the dose-response curves. The response of the developing mice to d-amphetamine is at variance with the known response of mature mice.
研究了不同剂量的d-苯丙胺对C57BL/6J小鼠（以其高活动水平著称）、DBA/1J、C3H/HeJ和C3D2F1小鼠（所有小鼠均为25至30日龄）活动水平的影响。活动通过使用带有旋转鼓的活动笼来测量。在确定基线活动水平后，将动物分为以下几组腹腔注射：（1）生理盐水，（2）0.2 mg/kg的d-苯丙胺，（3）0.5 mg/kg的d-苯丙胺，（4）5 mg/kg的d-苯丙胺。C57BL/6J小鼠的平均活动水平显著高于其他品系。在所有品系中，5 mg/kg剂量后的平均活动水平显著低于其他剂量后的水平。从剂量-反应曲线的平行概况可以明显看出，所有品系对d-苯丙胺的反应相似。发育中小鼠对d-苯丙胺的反应与成熟小鼠的已知反应不同。
