Piacibello W, Aglietta M, Gavosto F
Tumori. 1980 Jun 30;66(3):295-303. doi: 10.1177/030089168006600303.
Cell kinetic studies were performed in 8 case of lymphoid blastic crisis (BC) of chronic myeloid leukemia at the onset of BC and during subsequent relapses. The results were compared with those found in 7 myeloblastic BC. While in the myeloblastic transformation the labeling index (LI) was always higher in bone marrow than in peripheral blood blasts, suggesting a predominant bone marrow proliferation of the leukemic cells, in the lymphoid transformation a higher LI was often found in peripheral blasts. Moreover, the lymphoblastic transformations were frequently characterized by lymphadenopathy. These findings point to the similarities between lymphoid BC and acute lymphoblastic leukemia, suggesting the possibility that a blastic event may originate in an extramedullary site and that an extramedullary BC is more likely to be lymphoid in nature.
对8例慢性髓性白血病淋巴母细胞危象（BC）患者在BC发病时及随后复发期间进行了细胞动力学研究。将结果与7例髓母细胞性BC的结果进行了比较。在髓母细胞转化中，骨髓中的标记指数（LI）总是高于外周血母细胞，提示白血病细胞主要在骨髓增殖，而在淋巴母细胞转化中，外周血母细胞中常发现较高的LI。此外，淋巴母细胞转化常伴有淋巴结病。这些发现表明淋巴母细胞性BC与急性淋巴细胞白血病之间存在相似性，提示母细胞事件可能起源于髓外部位，且髓外BC在本质上更可能是淋巴母细胞性的。
