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职业与男性肺癌:瑞典北部的一项病例对照研究。

Occupation and male lung cancer: a case-control study in northern Sweden.

作者信息

Damber L A, Larsson L G

出版信息

Br J Ind Med. 1987 Jul;44(7):446-53. doi: 10.1136/oem.44.7.446.

DOI:10.1136/oem.44.7.446
PMID:3620367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1007858/
Abstract

Using a case-control study comprising about 600 men with lung cancer in northern Sweden the potential risk of different occupations and groups of occupations was studied. Longitudinal data concerning occupation, employment, and smoking habits were obtained by questionnaires. Some occupational groups (underground miners, copper smelter workers, electricians, and plumbers) exposed to previously known lung carcinogenic agents such as radon daughters, arsenic, and asbestos, had considerably increased odds ratios, which persisted after adjustment for smoking. A slightly raised odds ratio was observed in a group of blue collar workers potentially exposed to lung carcinogenic agents; this rise in the group as a whole mainly disappeared after adjustment for smoking. Farmers and foresters had strikingly low odds ratios, which could only partly be explained by their more moderate smoking habits. The population aetiological fraction attributable to occupation was estimated as 9%.

摘要

利用一项病例对照研究,该研究包含瑞典北部约600名肺癌男性患者,研究了不同职业和职业群体的潜在风险。通过问卷调查获得了有关职业、就业和吸烟习惯的纵向数据。一些接触过先前已知的肺癌致癌物质(如氡子体、砷和石棉)的职业群体(地下矿工、铜冶炼工人、电工和水管工)的优势比显著增加,在调整吸烟因素后该优势比依然存在。在一组可能接触肺癌致癌物质的蓝领工人中观察到优势比略有升高;在对吸烟因素进行调整后,该群体整体的这一升高主要消失了。农民和林业工人的优势比极低,这只能部分归因于他们较为适度的吸烟习惯。归因于职业的人群病因分数估计为9%。

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本文引用的文献

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Lung cancer mortality among U.S. uranium miners: a reappraisal.美国铀矿矿工的肺癌死亡率:重新评估
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Lung cancer in Swedish iron miners exposed to low doses of radon daughters.瑞典接触低剂量氡子体的铁矿工人中的肺癌
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