White W J, McLaughlin P J, Zagon I S
Pharmacology. 1978;17(4):227-32. doi: 10.1159/000136859.
Body weight gain and food and water consumption of female rats receiving daily methadone injections (5 mg/kg) intraperitoneally prior to mating and during gestation and lactation were studied. In contrast to saline-injected mothers, methadone-treated females had lower body weights throughout pregnancy, but gained weight during lactation; by postnatal day 21, both groups were of comparable body weight. No significant differences in food consumption throughout gestation or lactation were recorded. Total water consumption of methadone-treated rats was higher during the first 2 weeks of gestation and lactation, and lower during the 3rd week of lactation when compared to controls. These results demonstrate that methadone-treated rats have lower body weights throughout gestation and lactation, and that these weight deficits are not caused by insufficient food and water consumption.
研究了在交配前、妊娠期和哺乳期每天腹腔注射美沙酮（5毫克/千克）的雌性大鼠的体重增加以及食物和水的消耗量。与注射生理盐水的母鼠相比，接受美沙酮治疗的雌性大鼠在整个孕期体重较低，但在哺乳期体重增加；到出生后第21天，两组的体重相当。在整个妊娠期或哺乳期，未记录到食物消耗量有显著差异。与对照组相比，接受美沙酮治疗的大鼠在妊娠和哺乳期的前两周总饮水量较高，而在哺乳期的第三周较低。这些结果表明，接受美沙酮治疗的大鼠在整个妊娠和哺乳期体重较低，而且这些体重不足并非由食物和水的摄入量不足所致。
