Peeke H V, Dark K A, Salamy A, Salfi M, Shah S N
Department of Psychiatry, University of California, Eldridge 95431.
Pharmacol Biochem Behav. 1994 Jun;48(2):403-10. doi: 10.1016/0091-3057(94)90544-4.
In a model emphasizing prebreeding cocaine administration, rats exposed to cocaine (50 mg/kg) daily were compared to saline-injected and noninjected controls with respect to weight changes, food and water intake, maternal behavior, offspring weight, and activity. During the first 21 days cocaine-treated dams lost weight, while the control dams gained. Throughout gestation and the first 14 days of lactation all groups gained weight, but the cocaine-exposed dams never completely recovered from the initial anorectic effect. Except during the first week of exposure, cocaine dams ate and drank more than the normal controls and drank more than the saline group. During gestation there was no difference in food intake, although the cocaine dams continued to drink more than controls. During lactation there were no differences in food and water consumption across groups. However, the cocaine dams exhibited more nursing behavior. From birth to day 21, the offspring of cocaine-treated dams were smaller than those of either control group. By 51 days of age, group differences had disappeared. Cocaine-exposed pups and saline offspring tested at days 28 and 85 were more active than those of noninjected controls. The results indicate that administration of cocaine for a period prior to breeding and during gestation and lactation, a protocol which closely resembles human drug abuse patterns, is more devastating than the administration during gestation.
在一个强调繁殖前给予可卡因的模型中，将每天接受可卡因（50毫克/千克）处理的大鼠与注射生理盐水和未注射的对照组在体重变化、食物和水摄入量、母性行为、后代体重及活动方面进行了比较。在最初的21天里，接受可卡因处理的母鼠体重减轻，而对照组母鼠体重增加。在整个妊娠期和哺乳期的前14天，所有组的体重都增加了，但接触可卡因的母鼠从未从最初的厌食效应中完全恢复过来。除了接触的第一周外，接触可卡因的母鼠饮食比正常对照组多，且饮水比注射生理盐水组多。在妊娠期，食物摄入量没有差异，尽管接触可卡因的母鼠饮水仍比对照组多。在哺乳期，各组间食物和水的消耗量没有差异。然而，接触可卡因的母鼠表现出更多的护理行为。从出生到第21天，接受可卡因处理的母鼠的后代比两个对照组的后代都小。到51日龄时，组间差异消失。在第28天和第85天测试时，接触可卡因的幼崽和注射生理盐水的后代比未注射的对照组更活跃。结果表明，在繁殖前、妊娠期和哺乳期给予可卡因，这种方案与人类药物滥用模式非常相似，比在妊娠期给药更具破坏性。
