Gottlieb P, Wandall T, Overø K F
Acta Psychiatr Scand. 1980 Sep;62(3):236-44. doi: 10.1111/j.1600-0447.1980.tb00611.x.
Ten endogenously depressed inpatients were treated once daily for at least 4 weeks with 40-50 mg citalopram (Lu 10-171) - a specific serotonin reuptake inhibitor. The Hamilton rating scale for depression and global assessment indicated pronounced or moderate response in seven patients and slight or no response in three. Side effects were few, mild and transient and neither anticholinergic nor cardiotoxic effects were observed. No difference was observed between responders and non-responders as regards psychopathology, plasma levels or uptake inhibition. It is concluded, that citalopram seems to possess antidepressant properties and that controlled trials are wanted to evaluate its therapeutic value as well as the underlying hypothesis of serotonin - deficient depressions.
十名内因性抑郁症住院患者每日接受一次至少4周的40 - 50毫克西酞普兰（Lu 10 - 171）治疗，西酞普兰是一种特异性5-羟色胺再摄取抑制剂。汉密尔顿抑郁评定量表和综合评定显示，七名患者有显著或中度反应，三名患者有轻微或无反应。副作用少、轻微且短暂，未观察到抗胆碱能或心脏毒性作用。在精神病理学、血浆水平或摄取抑制方面，反应者和无反应者之间未观察到差异。结论是，西酞普兰似乎具有抗抑郁特性，需要进行对照试验来评估其治疗价值以及5-羟色胺缺乏性抑郁症的潜在假说。
