使用西酞普兰（LU 10 - 171）（一种特异性5 - 羟色胺再摄取抑制剂）作为抗抑郁药的初步研究。
Preliminary studies with citalopram (LU 10-171), a specific 5-HT-reuptake inhibitor, as antidepressant.
作者信息
Gastpar M, Gastpar G
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(3):319-25. doi: 10.1016/s0278-5846(82)80182-6.
PMID:6959196
Abstract
- Ten hospitalized, depressive, female patients above the age of 50 have been treated in a 3 week open trial with citalopram, a specific 5-HT-uptake inhibitor. 2. Six full and two partial responders demonstrate a recovery rate within the well known range for tricyclic antidepressant drugs. 3. Early onset of clinical effect and minimal side effects indicate that citalopram is possible a new effective antidepressant.
摘要
- 10名年龄在50岁以上住院治疗的抑郁症女性患者，接受了为期3周的西酞普兰开放试验，西酞普兰是一种特异性5-羟色胺摄取抑制剂。2. 6名完全缓解者和2名部分缓解者的恢复率处于三环类抗抑郁药的已知有效范围内。3. 临床效果起效早且副作用最小，表明西酞普兰可能是一种新型有效的抗抑郁药。
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