Paasonen M K, Penttilä O, Himberg J J, Solatunturi E
Acta Med Scand Suppl. 1980;642:79-84. doi: 10.1111/j.0954-6820.1980.tb10938.x.
The content of taurine in the hypertrophied left ventricle is increased in congestive heart failure an in spontaneously hypertensive (SH) rats. In SH rats the taurine content of and taurine uptake by the platelets are also increased. The present results indicate that, as in the heart, the taurine content may also increase in the platelets of those patients with congestive heart failure. The taurine content and uptake are not increased in the platelets of hypertensive patients as they are in the platelets of SH rats. It is likely that in acute myocardial infarction, a considerable amount of taurine is released from the heart into the plasma. However, there is no simultaneous increase in the platelet taurine content. From this work on can only conclude that platelets may reflect taurine changes in the heart in some pathological states, e.g. congestive heart failure.
在充血性心力衰竭患者以及自发性高血压(SH)大鼠中,肥厚左心室的牛磺酸含量会增加。在SH大鼠中,血小板的牛磺酸含量及其对牛磺酸的摄取也会增加。目前的结果表明,与心脏情况一样,充血性心力衰竭患者血小板中的牛磺酸含量可能也会增加。高血压患者血小板中的牛磺酸含量和摄取量不像SH大鼠血小板那样增加。在急性心肌梗死时,很可能有相当数量的牛磺酸从心脏释放到血浆中。然而,血小板中的牛磺酸含量并没有同时增加。从这项研究只能得出结论,在某些病理状态下,如充血性心力衰竭,血小板可能反映心脏中牛磺酸的变化。