色素性视网膜炎中血小板对牛磺酸的摄取。

Uptake of taurine by platelets in retinitis pigmentosa.

作者信息

Airaksinen E M, Sihvola P, Airaksinen M M, Sihvola M, Tuovinen E

出版信息

Lancet. 1979 Mar 3;1(8114):474-5. doi: 10.1016/s0140-6736(79)90826-2.

Abstract

Uptake of 3H-taurine by platelets from twelve patients with retinitis pigmentosa (R.P.) and from healthy controls was measured. Platelets were incubated in autologous plasma with 3H-taurine for different times and at different substrate concentrations. The uptake of taurine by R.P. platelets at each incubation time was about two-thirds of the control value, the difference being statistically significant. Km was about the same, but Vmax was lower in R.P. platelets. The results suggest that R.P. is a disease affecting not only the eye but also taurine transport and/or storage in general.

摘要

对12名视网膜色素变性（R.P.）患者和健康对照者的血小板摄取³H-牛磺酸的情况进行了测量。将血小板在含有³H-牛磺酸的自体血浆中于不同时间和不同底物浓度下进行孵育。在每个孵育时间，R.P.患者血小板对牛磺酸的摄取量约为对照值的三分之二，差异具有统计学意义。米氏常数（Km）大致相同，但R.P.患者血小板的最大反应速度（Vmax）较低。结果表明，视网膜色素变性不仅是一种影响眼睛的疾病，而且总体上还会影响牛磺酸的转运和/或储存。