Rybakova L P, Tiagotin Iu V, Kharchenko M F
Vopr Med Khim. 1981 Jan-Feb;27(1):80-3.
A rate of oxygen consumption by granulocytes was measured before cell stimulation and following their stimulation by zymosan in healthy persons and in patients with chronic myelocytic leukemia (CML). The rate of oxygen consumption by granulocytes of donors was higher than that of patients with CML. Addition of lysosomal acid soluble proteins, extracted from normal granulocytes, affected the respiratory activity of stimulated and non-stimulated both normal and leukemic cells, depending upon the protein concentration. The alterations were more marked in granulocytes of donors. Lysosomal acid soluble proteins, extracted from granulocytes of patients with CML did not change the cell respiratory activity.
在健康人和慢性粒细胞白血病（CML）患者中，测量了粒细胞在细胞刺激前以及经酵母聚糖刺激后的耗氧率。供体粒细胞的耗氧率高于CML患者。添加从正常粒细胞中提取的溶酶体酸溶性蛋白质，根据蛋白质浓度的不同，会影响正常和白血病细胞在刺激和未刺激状态下的呼吸活性。供体粒细胞中的变化更为明显。从CML患者粒细胞中提取的溶酶体酸溶性蛋白质不会改变细胞的呼吸活性。
