Skotnikova O I, Sevast'ianova M G, Borisov B N, Fedorov N A
Biull Eksp Biol Med. 1980 Apr;89(4):457-9.
The filtration-fluorescence technique was used to estimate the number of DNA breaks in leukocytes of patients with chronic lympholeukemia (CLL) and chronic myelo-leukemia (CML). Leukocytes from CLL patients showed 1.5-3-fold higher level of DNA breaks in comparison to normal lymphocytes, the number of breaks correlated with the disease progress. The patients with CML also displayed the increased DNA break level. It was 4.4 times as high as that in normal lymphocytes and 1.5 as high as compared to normal granulocytes. In malignant course of the disease (2 cases), the level of DNA breaks in leukocytes was determined as 8-30 times higher than normal.
采用过滤-荧光技术评估慢性淋巴细胞白血病（CLL）和慢性粒细胞白血病（CML）患者白细胞中的DNA断裂数量。与正常淋巴细胞相比，CLL患者白细胞中的DNA断裂水平高出1.5至3倍，断裂数量与疾病进展相关。CML患者也表现出DNA断裂水平升高。其水平是正常淋巴细胞的4.4倍，是正常粒细胞的1.5倍。在该疾病的恶性病程中（2例），白细胞中的DNA断裂水平测定比正常水平高8至30倍。
