Jacquillat C, Tobelem G, Auclerc M F, Chastang C, Lechevallier T, Weil M, Daniel M T, Flandrin G, Harrousseau J L, Schaison G, Boiron M, Bernard J
Nouv Presse Med. 1980 Dec 13;9(47):3601-4.
Seventy-four patients with acute pure monoblastic leukaemia treated between 1970 and 1978 were studied retrospectively. The disease was usually hyperleucocytic and tumoral in character. It occurred with equal frequency in subjects of both sexes and at all ages, with peaks at the two extremes of life. Rubidazone gave a high percentage (75%) of complete remissions, but the prognosis remained sombre, with a mean survival time of 200 days. The incidence of meningeal relapses was reduced by prophylactic measures at central nervous system level, but gingival and cutaneous relapses were frequent. The possibility of bettering the present modest therapeutic results by more intensive chemotherapy is discussed.
对1970年至1978年间接受治疗的74例急性纯单核细胞白血病患者进行了回顾性研究。该疾病通常具有高白细胞血症和肿瘤性特征。在所有年龄段和男女患者中发病率相同，在生命的两个极端年龄段出现高峰。柔红霉素可使完全缓解率达到较高比例（75%），但预后仍然不佳，平均生存时间为200天。通过中枢神经系统层面的预防措施，脑膜复发的发生率有所降低，但牙龈和皮肤复发较为常见。讨论了通过更强化的化疗改善目前有限治疗效果的可能性。
