用咪康唑治疗的口腔组织胞浆菌病。

Oral histoplasmosis treated with miconazole.

作者信息

Nicholls M, Robertson T I, Jennis F

出版信息

Aust N Z J Med. 1980 Oct;10(5):563-5. doi: 10.1111/j.1445-5994.1980.tb04978.x.

DOI:10.1111/j.1445-5994.1980.tb04978.x

Abstract

A case of localised histoplasmosis of the gingivae, with no osseous involvement is described in a 50-year-old man. The diagnosis was based on histology, growth on culture and a positive histoplasmin latex test. Therapy was commenced with intravenous amphotericin but was changed to intravenous miconazole because of serious immediate side effects and the development of marked renal impairment and moderate suppression of erythropoiesis. Rebiopsy of the gingival margin showed therapy to be effective. No source of the infection could be traced.

摘要

本文描述了一名50岁男性牙龈局限性组织胞浆菌病病例，无骨质受累。诊断基于组织学、培养生长情况及组织胞浆菌素乳胶试验阳性。治疗开始时使用静脉注射两性霉素，但因严重的即刻副作用、明显的肾功能损害及中度红细胞生成抑制，改为静脉注射咪康唑。牙龈边缘再次活检显示治疗有效。未发现感染源。