Department of Food Biotechnology, Medical University of Bialystok, Szpitalna 37 Street, 15-295 Bialystok, Poland.
Department of Gynaecology and Practical Obstetrics, Medical University of Bialystok, M. Sklodowskiej-Curie 24A Street, 15-089 Bialystok, Poland.
Int J Mol Sci. 2024 Jul 2;25(13):7292. doi: 10.3390/ijms25137292.
Cancer development is related to genetic mutations in primary cells, where 5-10% of all cancers are derived from acquired genetic defects, most of which are a consequence of the environment and lifestyle. As it turns out, over half of cancer deaths are due to the generation of drug resistance. The local delivery of chemotherapeutic drugs may reduce their toxicity by increasing their therapeutic dose at targeted sites and by decreasing the plasma levels of circulating drugs. Nanobubbles have attracted much attention as an effective drug distribution system due to their non-invasiveness and targetability. This review aims to present the characteristics of nanobubble systems and their efficacy within the biomedical field with special emphasis on cancer treatment. In vivo and in vitro studies on cancer confirm nanobubbles' ability and good blood capillary perfusion; however, there is a need to define their safety and side effects in clinical trials.
癌症的发生与原代细胞中的基因突变有关，其中 5-10%的癌症源自后天获得的遗传缺陷，这些缺陷大多是环境和生活方式的结果。事实证明，超过一半的癌症死亡是由于产生了耐药性。化疗药物的局部递送可以通过在靶向部位增加治疗剂量和降低循环药物的血浆水平来降低其毒性。纳米气泡由于其非侵入性和靶向性而引起了人们的广泛关注，成为一种有效的药物传递系统。本综述旨在介绍纳米气泡系统的特性及其在生物医学领域的疗效，特别强调癌症治疗。癌症的体内和体外研究证实了纳米气泡的能力和良好的血毛细血管灌注；然而，仍需要在临床试验中确定其安全性和副作用。
