Senekowitsch R, Kriegel H
Nuklearmedizin. 1980 Aug;19(4):200-5.
The cytostatic action of Adriblastin on the accumulation of 99mTc-MDP by a transplantable osteogenic sarcoma in the mouse was investigated. The quantitative determination of the activity concentration in the tumor showed a concentration value 8 days after the administration of the cytostatic which was nearly twice that found in the untreated animals. This could be clearly observed in scintigrams obtained with a gamma-camera using a pinhole-collimator. The histoautoradiography likewise showed a higher concentration of the radiopharmaceutical which can be attributed to higher ossification within the tumor due to the application of the cytostatic agent. Our results indicate that scintigraphy with 99mTc-MDP is a good follow-up method during treatment with cytostatics.
研究了阿霉素对小鼠可移植性骨肉瘤摄取99mTc-MDP的细胞抑制作用。对肿瘤中活性浓度的定量测定显示，在给予细胞抑制剂8天后的浓度值几乎是未治疗动物的两倍。这在使用针孔准直器的γ相机获得的闪烁图中可以清楚地观察到。组织放射自显影同样显示放射性药物的浓度较高，这可归因于由于应用细胞抑制剂而导致肿瘤内更高的骨化。我们的结果表明，99mTc-MDP闪烁扫描是细胞抑制剂治疗期间一种良好的随访方法。
