Gad A, Rowlatt C, Sheriff M U
Acta Pathol Microbiol Scand A. 1977 May;85(3):311-8. doi: 10.1111/j.1699-0463.1977.tb00431.x.
The mucosubstances in a series of 12 mammary carcinomas arising in C57BL mice were compared with those in tumours in nine C3H mice and with normal "resting" and lactating glands. A strain difference rather than a difference according to tumour type was found. The epithelial elements in the C57BL tumours contained mainly sialomucin with a little neutral mucosubstance and sulphomucin was present in some. Sulphated mucopolysaccharide was prominent in the stroma of these tumours. The C3H mice tumours contained no sulphomucin, less sialomucin but more neutral mucosubstance. The mucosubstances were studied in serial transplants of four tumours. An acid to neutral mucosubstance change with dedifferentiation of the tumour has been observed and found to be similar to a series of changes previously observed in a group of human gastrointestinal tumours.
将一系列在C57BL小鼠中发生的12例乳腺癌中的黏液物质，与9只C3H小鼠肿瘤中的黏液物质以及正常“静止”和泌乳乳腺中的黏液物质进行了比较。发现存在品系差异而非肿瘤类型差异。C57BL肿瘤中的上皮成分主要含有涎黏蛋白，有少量中性黏液物质，部分含有硫酸黏蛋白。硫酸化黏多糖在这些肿瘤的基质中很突出。C3H小鼠肿瘤不含硫酸黏蛋白，涎黏蛋白较少但中性黏液物质较多。对4个肿瘤的连续移植瘤中的黏液物质进行了研究。观察到随着肿瘤去分化，酸性黏液物质向中性黏液物质转变，并且发现这与先前在一组人类胃肠道肿瘤中观察到的一系列变化相似。
