Dionne R A, Driscoll E J, Gelfman S S, Sweet J B, Butler D P, Wirdzek P R
J Oral Surg. 1981 May;39(5):343-9.
The cardiovascular and respiratory responses to a combination of diazepam and methohexital (D-M) were compared to those from a combination of diazepam, fentanyl, and methohexital (D-F-M). Both caused significant tachycardia after administration and during surgery. The D-F-M combination caused a significant decrease in both respiration rate and oxygen saturation. Surgeons preferred this combination for the production of sedation and cooperation of patients. Comparison of efficacy to toxicity suggests that the increase in patient cooperation for the D-F-M combination is at the expense of respiratory depression. The use of oxygen supplementation and monitoring of respiration is recommended during the use of the combination.
将地西泮和甲己炔巴比妥（D-M）联合使用时的心血管和呼吸反应与地西泮、芬太尼和甲己炔巴比妥（D-F-M）联合使用时的反应进行了比较。两种联合用药在给药后及手术期间均引起显著的心动过速。D-F-M联合用药导致呼吸频率和血氧饱和度显著下降。外科医生更喜欢这种联合用药用于患者的镇静和配合。疗效与毒性的比较表明，D-F-M联合用药时患者配合度的提高是以呼吸抑制为代价的。建议在使用该联合用药时进行氧气补充和呼吸监测。
