Stewart F A, Denekamp J
Br J Radiol. 1980 Apr;53(628):346-56. doi: 10.1259/0007-1285-53-628-346.
The combined effects of single and fractionated doses of X rays and local heat were investigated using an experimental fibrosarcoma and normal mouse skin. Thermal enhancement ratios were measured from pairs of dose-response curves for both tumour and skin, and the therapeutic advantage of each treatment was then assessed by comparing the enhancement for tumour and skin. For single doses there was a therapeutic advantage when heat was applied three hours after X rays but not with heat applied immediately after irradiation. For two and five daily fractions with heat immediately after irradiation there was significantly less thermal sensitization in tumour than in skin; hence there was a therapeutic loss. When heat was applied at three hours after each fraction there was no thermal sensitization in either skin or tumour; the therapeutic ratio was therefore 1.0. The repair capacity of skin after fractionated X rays alone, or in combination with heat, was also investigated. Heat immediately after X rays caused a small decrease in the repair capacity between two fractions but no decreased repair capacity was observed with five fractions.
使用实验性纤维肉瘤和正常小鼠皮肤研究了单次和分次剂量X射线与局部加热的联合效应。从肿瘤和皮肤的剂量反应曲线对中测量热增强比，然后通过比较肿瘤和皮肤的增强情况来评估每种治疗方法的治疗优势。对于单次剂量，在X射线照射后3小时施加热量时有治疗优势，但在照射后立即施加热量则没有。对于每日2次和5次分次照射且在照射后立即施加热量的情况，肿瘤中的热敏化明显少于皮肤；因此存在治疗损失。当在每次分次照射后3小时施加热量时，皮肤或肿瘤中均未出现热敏化；因此治疗比为1.0。还研究了单独分次X射线照射或与加热联合照射后皮肤的修复能力。X射线照射后立即施加热量会导致两次分次照射之间的修复能力略有下降，但在5次分次照射时未观察到修复能力下降。
