Benveniste J, Roubin R, Chignard M, Jouvin-Marche E, Le Couedic J P
Agents Actions. 1982 Dec;12(5-6):711-3. doi: 10.1007/BF01965088.
The release and formation of PAF-acether and of its deacetylated precursor (2-lyso PAF-acether) have been determined on mouse macrophages (M phi), human polymorphonuclear neutrophils (PMN) and rabbit platelets using specific secretagogue stimuli in the same experimental conditions. It was found that as opposed to M phi, PMN and platelets were good releasers of PAF-acether. However, the total amount of PAF-acether formed by M phi and PMN was larger than that formed by platelets. The total amount of 2-lyso PAF-acether varied also for the three cell types, with platelets being by far the best producer. Calculation of the amount of PAF-acether formed from 2-lyso PAF-acether indicated that M phi and PMN possess a higher acetylating ability than platelets.
在相同实验条件下，使用特定的促分泌剂刺激，已测定了小鼠巨噬细胞（M phi）、人多形核中性粒细胞（PMN）和兔血小板中血小板活化因子（PAF-乙醚）及其去乙酰化前体（2-溶血PAF-乙醚）的释放和形成情况。结果发现，与M phi不同，PMN和血小板是PAF-乙醚的良好释放者。然而，M phi和PMN形成的PAF-乙醚总量大于血小板形成的总量。三种细胞类型的2-溶血PAF-乙醚总量也有所不同，其中血小板是迄今为止最佳的生产者。由2-溶血PAF-乙醚形成的PAF-乙醚量的计算表明，M phi和PMN比血小板具有更高的乙酰化能力。
