Hsieh D S, Langer R, Folkman J
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1863-7. doi: 10.1073/pnas.78.3.1863.
Sustained-release systems were made by incorporating bovine serum albumin and magnetic steel beads in an ethylene-vinyl acetate copolymer matrix. When exposed to aqueous medium, the polymer matrix released the albumin slowly and continuously. Application of an oscillating magnetic field increased the release rate by as much as 100%. Intervals of 6-hr periods of magnetic exposure and nonexposure were alternated over a 5-day period, resulting in corresponding increases and decreases in release and establishing a pattern of modulated sustained release.
通过将牛血清白蛋白和磁钢珠掺入乙烯-醋酸乙烯酯共聚物基质中来制备缓释系统。当暴露于水性介质时，聚合物基质会缓慢且持续地释放白蛋白。施加振荡磁场可使释放速率提高多达100%。在5天的时间内交替进行6小时的磁暴露和非暴露间隔，导致释放相应地增加和减少，并建立了一种调节缓释模式。
