Bessho F, Fujiu M, Kinumaki H
Am J Clin Pathol. 1981 May;75(5):684-92. doi: 10.1093/ajcp/75.5.684.
An ultrastructural study of four cases of acute nonlymphocytic leukemia with abnormal nuclear lobulation was done. These cases were classified as M3 (Case 1), M3 variant (Cases 2 and 3), and M5, differentiated type (Case 4), on the basis of light microscopy according to the FAB classification. Ultrastructural observation of the leukemic cells of Cases 2 and 3 showed large bundles of fibrils in addition to abnormalities in the endoplasmic reticulum and granules, as had been reported in cases of acute promyelocytic leukemia. Large bundles of fibrils and abnormal nuclear lobulation also seemed to be characteristic of the M3 variant. However, the relationship between these structures was not identified. The exact nature of nuclear lobulation is not known, but seems to be related to some kind of intrinsic force and may be a presentation of the premature occurrence of lobulation intrinsic to the granulocyte or monocyte nucleus.
对4例伴有异常核分叶的急性非淋巴细胞白血病进行了超微结构研究。根据FAB分类，在光镜下，这些病例被分类为M3（病例1）、M3变异型（病例2和3）以及M5分化型（病例4）。病例2和3的白血病细胞超微结构观察显示，除内质网和颗粒异常外，还有大量的原纤维束，正如急性早幼粒细胞白血病病例中所报道的那样。大量的原纤维束和异常核分叶似乎也是M3变异型的特征。然而，这些结构之间的关系尚未明确。核分叶的确切性质尚不清楚，但似乎与某种内在力量有关，可能是粒细胞或单核细胞核分叶过早出现的一种表现。
