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[慢性髓细胞白血病急变期的核型。II. 17三体]

[Karyotype in chronic myeloid leukemia in a blastic crisis. II. Trisomy 17].

作者信息

Geraci L, Palka G, Felaco M, Miscia S, D'Antuono A, Caramelli E

出版信息

Boll Soc Ital Biol Sper. 1981 Jan 30;57(2):149-51.

PMID:6940606
Abstract

One case of a patient with Chronic Granulocytic Leukemia showing a double Ph' together with trisomy 17 during blastic crisis is reported. The Ph' chromosome resulting from a standard translocation of the chromosomes 9 and 22 was present in all the 16 mitoses observed, while the trisomy 17 was found in 15. This case is an additional contribution which demonstrates the presence of the alterations of the chromosome group E during the blastic crisis.

摘要

报告了1例慢性粒细胞白血病患者在原始细胞危象期间出现双Ph'染色体以及17号染色体三体的病例。由9号和22号染色体标准易位产生的Ph'染色体在观察到的所有16个有丝分裂中均存在,而17号染色体三体在15个有丝分裂中被发现。该病例进一步证明了在原始细胞危象期间存在E组染色体的改变。

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