克隆衰减模型。
A model of clonal attenuation.
作者信息
Prothero J, Gallant J A
出版信息
Proc Natl Acad Sci U S A. 1981 Jan;78(1):333-7. doi: 10.1073/pnas.78.1.333.
Two formal models of clonal attenuation [Kirkwood, T. B. L. & Holliday, R. (1975) J. Theor. Biol. 53, 481-496; Shall, S. & Stein, W. D. (1979) J. Theor. Biol. 76, 219-231] are considered in the light of recent data on the changing distribution of replicative potential among individual cultured fibroblasts on subcloning. The experimental data [Smith, J. R., Pereira-Smith, O. & Good, P. I. (1977) Mech. Ageing Dev. 6, 283-286] are shown to contradict both models. A new model, compatible with the subcloning data, is proposed. This model involves a gradual increase in the probability of commitment during cell growth in culture and a small number (about seven) of divisions following commitment. The gradual increase in commitment probability is shown to be compatible with the gradual accumulation of a gene product subject to autogenous regulation.
根据最近关于亚克隆时单个培养成纤维细胞中复制潜力变化分布的数据，对克隆衰减的两种形式模型[柯克伍德，T.B.L.和霍利迪，R.（1975年）《理论生物学杂志》53卷，481 - 496页；沙尔，S.和斯坦，W.D.（1979年）《理论生物学杂志》76卷，219 - 231页]进行了考量。实验数据[史密斯，J.R.、佩雷拉 - 史密斯，O.和古德，P.I.（1977年）《衰老与发育机制》6卷，283 - 286页]表明与这两种模型均相矛盾。提出了一个与亚克隆数据相符的新模型。该模型涉及培养细胞生长过程中定向概率的逐渐增加以及定向后少量（约七次）的分裂。定向概率的逐渐增加被证明与受自身调节的基因产物的逐渐积累相符。
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