Scarpelli D G, Rao M S
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2577-81. doi: 10.1073/pnas.78.4.2577.
Differentiation is the process by which multicellular organisms achieve the specialized functions necessary for adaptation and survival. An in vivo model in the Syrian golden hamster is described in which regenerating pancreatic cells are converted into hepatocyte-like cells, as evidenced by the presence of albumin, peroxisomes, and a variety of morphological markers. These cells are stable after the conversion is triggered by a single dose of the carcinogen N-nitrosobis(2-oxopropyl)amine administered during the S phase in regenerating pancreatic cells. This suggests that, given the proper stimulus, regenerating cells in adult pancreas can be redirected into a totally different pathway of differentiation.
分化是多细胞生物实现适应和生存所需的特殊功能的过程。本文描述了一种叙利亚金仓鼠体内模型，其中再生的胰腺细胞可转化为肝细胞样细胞，白蛋白、过氧化物酶体和多种形态学标志物的存在证明了这一点。在再生胰腺细胞的S期给予单剂量致癌物N-亚硝基双（2-氧代丙基）胺触发转化后，这些细胞是稳定的。这表明，在适当的刺激下，成年胰腺中的再生细胞可以被重定向到完全不同的分化途径。
