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大豆粉和N-亚硝基双(2-氧代丙基)胺对仓鼠胰腺的影响。

The effects of soy flour and N-nitrosobis (2-oxopropyl) amine on the pancreas of the hamster.

作者信息

Hasdai A, Liener I E

出版信息

Drug Nutr Interact. 1985;3(3):173-9.

PMID:4040846
Abstract

Syrian golden hamsters fed diets of raw or heated soy flour for 16 months had an incidence (4%) of pancreatic neoplasms in both groups. Animals injected with N-nitrosobis (2-oxopropyl) amine (BOP) and fed heated soy flour for 15 months developed a high incidence (88%) of microscopic benign and malignant neoplasms, primarily of ductal origin. This was in marked contrast to a similar group of BOP-injected animals which had been fed raw soy flour and in which the incidence of pancreatic neoplasms was less than 10%.

摘要

用生大豆粉或加热大豆粉喂养16个月的叙利亚金黄地鼠,两组胰腺肿瘤的发生率均为4%。注射N-亚硝基双(2-氧代丙基)胺(BOP)并喂养加热大豆粉15个月的动物,显微镜下良性和恶性肿瘤的发生率很高(88%),主要起源于导管。这与另一组注射BOP并喂养生大豆粉的动物形成鲜明对比,该组动物胰腺肿瘤的发生率不到10%。

相似文献

1
The effects of soy flour and N-nitrosobis (2-oxopropyl) amine on the pancreas of the hamster.大豆粉和N-亚硝基双(2-氧代丙基)胺对仓鼠胰腺的影响。
Drug Nutr Interact. 1985;3(3):173-9.
2
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Augmentation of carcinogenesis by N-nitrosobis(2-oxopropyl)amine administered during S phase of the cell cycle in regenerating hamster pancreas.在再生仓鼠胰腺细胞周期的S期给予N-亚硝基双(2-氧代丙基)胺对致癌作用的增强
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Effects of the interaction of dietary fat and protein on N-nitrosobis(2-oxopropyl)amine-induced carcinogenesis and spontaneous lesions in Syrian golden hamsters.膳食脂肪与蛋白质的相互作用对叙利亚金仓鼠中N-亚硝基双(2-氧代丙基)胺诱导的致癌作用及自发性病变的影响。
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引用本文的文献

1
On the role of cholecystokinin in pancreatic cancer.关于胆囊收缩素在胰腺癌中的作用。
Int J Pancreatol. 1995 Apr;17(2):121-38. doi: 10.1007/BF02788530.