Modai D, Weissgarten J, Zolf R, Peller S, Averbukh Z, Kaufman S, Shaked U, Cohen N, Golik A, Tieder M
Nephrology Institute, Assaf Harofeh Medical Center, Sackler School of Medicine, Zerifin, Israel.
Nephron. 1988;49(3):237-9. doi: 10.1159/000185062.
Uremic granulocyte chemotaxis was assessed in the presence of four different concentrations of levamisole. Chemotactic responsiveness of uremic granulocytes was significantly decreased compared to normal, both in the absence of levamisole and with all levamisole concentrations tested. However, with 10(-3) and 10(-4) M levamisole concentrations, uremic granulocyte chemotaxis was similar to that of normal granulocytes without levamisole. Defective chemotactic activity of granulocytes may play a role in the increased susceptibility of uremic patients to infections. Pharmacological correction of this defect may improve the patients' ability to cope with infections.
在四种不同浓度的左旋咪唑存在的情况下评估尿毒症患者粒细胞的趋化性。与正常情况相比，无论在不存在左旋咪唑还是在所有测试的左旋咪唑浓度下，尿毒症患者粒细胞的趋化反应性均显著降低。然而，在左旋咪唑浓度为10⁻³和10⁻⁴ M时，尿毒症患者粒细胞的趋化性与未使用左旋咪唑的正常粒细胞相似。粒细胞趋化活性缺陷可能在尿毒症患者对感染易感性增加中起作用。对这一缺陷进行药理学纠正可能会提高患者应对感染的能力。
