一些疾病的上位性双基因座模型。II. 连锁与关联的混杂
Some epistatic two-locus models of disease. II. The confounding of linkage and association.
作者信息
Hodge S E, Spence M A
出版信息
Am J Hum Genet. 1981 May;33(3):396-406.
Abstract
This paper continues to examine the model discussed in the preceding paper. Specifically, it will be shown how a linkage analysis performed in the presence of a disease-marker association can give rise to erroneous and misleading results.
摘要
本文继续探讨前文所讨论的模型。具体而言，将展示在存在疾病-标记物关联的情况下进行连锁分析如何会产生错误和误导性的结果。
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引用本文的文献
1
Linkage analysis of "necessary" disease loci versus "susceptibility" loci.“必需”疾病基因座与“易感性”基因座的连锁分析。
Am J Hum Genet. 1993 Jan;52(1):135-43.
2
Linkage analysis versus association analysis: distinguishing between two models that explain disease-marker associations.连锁分析与关联分析：区分两种解释疾病-标记物关联的模型。
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3
Epistatic association and linkage analysis in human families.人类家系中的上位性关联与连锁分析。
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Evidence for recessive and against dominant inheritance at the HLA-"linked" locus in coeliac disease.乳糜泻中HLA“连锁”位点隐性遗传及非显性遗传的证据。
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本文引用的文献
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The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type.椭圆形红细胞增多症基因与Rh血型之间连锁关系的检测与评估。
Am J Hum Genet. 1956 Jun;8(2):80-96.
2
HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees.人类白细胞抗原与多发性硬化症的遗传：72个家系的连锁分析
Am J Hum Genet. 1980 Jan;32(1):103-11.
3
4
5
Analysis of linkage between the major histocompatibility system and juvenile, insulin-dependent diabetes in multiplex families. Reanalysis of data.对多个家庭中主要组织相容性系统与青少年胰岛素依赖型糖尿病之间的连锁分析。数据重新分析。
J Clin Invest. 1978 Aug;62(2):492-5. doi: 10.1172/JCI109151.
6
Hypertrophic cardiomyopathy.肥厚型心肌病
N Engl J Med. 1979 Aug 23;301(8):442-3. doi: 10.1056/NEJM197908233010829.
7
Genetic linkage between hereditary hemochromatosis and HLA.遗传性血色素沉着症与人类白细胞抗原之间的基因连锁
Am J Hum Genet. 1979 Sep;31(5):601-19.
8
Is juvenile diabetes determined by a single gene closely linked to HLA?青少年糖尿病是由与HLA紧密连锁的单个基因决定的吗？
Diabetes. 1979 Jun;28(6):527-32. doi: 10.2337/diab.28.6.527.
9
Evidence for a specific B27-associated cell surface marker on lymphocytes of patients with ankylosing spondylitis.强直性脊柱炎患者淋巴细胞上存在特定B27相关细胞表面标志物的证据。
Nature. 1979 Jan 4;277(5691):68-70. doi: 10.1038/277068a0.
10
Hypertrophic cardiomyopathy and human leukocyte antigen linkage: differentiation of two forms of hypertrophic cardiomyopathy.肥厚型心肌病与人类白细胞抗原连锁关系：两种肥厚型心肌病的鉴别
N Engl J Med. 1979 Apr 19;300(16):877-82. doi: 10.1056/NEJM197904193001602.
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