1型（胰岛素依赖型）糖尿病中HLA与免疫球蛋白抗原的相互作用。

Interaction of HLA and immunoglobulin antigens in type 1 (insulin-dependent) diabetes.

作者信息

Field L L, Anderson C E, Neiswanger K, Hodge S E, Spence M A, Rotter J I

出版信息

Diabetologia. 1984 Nov;27(5):504-8. doi: 10.1007/BF00290384.

Abstract

We analyzed 88 unrelated subjects with Type 1 (insulin-dependent) diabetes and 64 sibling controls (maximum one per diabetic) for associations between immunoglobulin allotype antigens (GM and KM) and Type 1 diabetes. None were found. However, we did find interactions between GM, HLA-DR, and Type 1 diabetes (significant or of borderline significance after considering the effect of multiple tests): possession of Glm(2) appeared to increase susceptibility to diabetes in individuals who had HLA-DR3 but not HLA-DR4, while possession of G3m(5) appeared to increase susceptibility in individuals who had HLA-DR4 but not HLA-DR3. These results suggest that genetic predisposition to Type 1 diabetes is partially determined by alleles at the GM locus (or a locus in linkage disequilibrium with GM) interacting with alleles at the HLA-DR locus (or a locus in linkage disequilibrium with HLA-DR).

摘要

我们分析了88名非亲属的1型（胰岛素依赖型）糖尿病患者以及64名同胞对照（每位糖尿病患者最多一名同胞对照），以研究免疫球蛋白同种异型抗原（GM和KM）与1型糖尿病之间的关联。未发现相关关联。然而，我们确实发现GM、HLA - DR与1型糖尿病之间存在相互作用（在考虑多次检验的影响后具有显著或临界显著意义）：拥有Glm(2)似乎会增加携带HLA - DR3但不携带HLA - DR4个体患糖尿病的易感性，而拥有G3m(5)似乎会增加携带HLA - DR4但不携带HLA - DR3个体的易感性。这些结果表明，1型糖尿病的遗传易感性部分由GM基因座（或与GM处于连锁不平衡的基因座）的等位基因与HLA - DR基因座（或与HLA - DR处于连锁不平衡的基因座）的等位基因相互作用决定。