人类白细胞抗原与多发性硬化症的遗传：72个家系的连锁分析
HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees.
作者信息
Tiwari J L, Hodge S E, Terasaki P I, Spence M A
出版信息
Am J Hum Genet. 1980 Jan;32(1):103-11.
Abstract
Linkage analysis of 72 pedigrees by the maximum-likelihood method provides evidence of linkage between HLA and the hypothesized multiple sclerosis susceptibility gene (MSSG) for both the dominant and recessive models of inheritance and for penetrance values ranging from 5%--65% (or higher). This MSSG, if it exists, is most likely located at 15%--20% recombination units from the HLA complex, probably on the B-D side. The analysis also shows that there is no heterogeneity in the estimates of linkage, and lod scores are not artifically inflated because of the association of multiple sclerosis (MS) with HLA-B7.
摘要
通过最大似然法对72个家系进行连锁分析，结果表明，对于显性和隐性遗传模式以及5% - 65%（或更高）的外显率值，HLA与假定的多发性硬化症易感基因（MSSG）之间存在连锁证据。如果这个MSSG存在，它很可能位于距HLA复合体15% - 20%重组单位处，可能在B - D侧。分析还表明，连锁估计不存在异质性，并且由于多发性硬化症（MS）与HLA - B7的关联，连锁值不会被人为夸大。
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